INTERACTIONS OF GRAPEFRUIT WITH MEDICATIONS
Interaction of Grapefruit Juice with Antihistamines
The most significant interaction of grapefruit juice occurred with anithistamines. Do not take grapefruit juice if you are taking terfenadine (seldane) or astemizole (Hismanal) due to the possibility of fatal cardiac arrhythmias. Other non-sedating antihistamines are available which do not appear to interact with grapefruit juice. (e.g., loratidine (Claritin) cetirizine (Reactine) or fexofenadine (Allegra).
In Australia, it is routine practice to add auxiliary labelling to prescriptions for terfenadine warning of grapefruit-juice drug interactions. In the United States, the manufacturer of terfenadine has changed its prescribing information to indicate that GJ should not be taken with
To study the effect of grapefruit juice on terfenadine 12 healthy subjects were given terfenadine 60 mg with either water or grapefruit juice, co-administered with terfenadine or delayed by 2 hours.
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