Mixers believe that diseases can develop from other causes, like bacteria and viruses. But they believe that subluxations affect the body's health by lowering resistance to disease. The deviation or malposition of a spinal vertebra may cause a neurological imbalance within the body, setting the stage for a lowered resistance.

Mixers comprise the majority of practitioners. Their practice extends beyond the narrow focus on vertebral subluxation. They use a wider range of modalities as well as concepts from diverse health care traditions in their practice. Many integrate methods from other traditions. The most common are: nutritional supplementation, vitamins, homeopathic drugs, and nutritional advice. Some integrate Chinese medicine, Ayurveda, naturopathy, homeopathy, massage or bodywork, mind/body approaches, or other healing methods into their offerings. Individual chiropractors often develop their own unique reputation and synthesis of different traditions. 

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