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| Sleep |  |
Fluoxetine (Prozac)
Brand Names
Prozac
Drug class: Antidepressant (selective serotonin reuptake inhibitor)
Uses
 | Treats mental depression, particularly in people who do not tolerate tricyclic antidepressants. |
| Treats obsessive-compulsive disorder. |
| Treats bulimia. |
| Treats geriatric depression. |
What drug does
Affects serotonin, one of the chemicals in the brain called neurotransmifters, that plays a role in emotions and psychological disturbances.
CNS activity - serotonin agonist.
Time lapse before drug works: 1 to 3 weeks.
Dosage
Common initial dose - 20 mg daily
Usual maximal dose - 80 mg
Don't take with
| Any monoamine oxidase (MAO) inhibitor, or within 14 days of stopping one. To do so may result in a serious or fatal reaction. |
| Any other medicine without consulting your doctor or pharmacist. |
Symptoms: Seizures, agitation, violent vomiting.
What To Do In Case of Overdose: Dial 911 (emergency) or 0 (operator) for an ambulance or medical help. Then give first aid immediately.
Interactions
| Possible Adverse Reactions Or Side Effects | |
| Symptoms | What To Do |
| Life-threatening: Rash, itchy skin, breathing difficulty (allergic reaction), chest pain. |
Seek emergency treatment immediately. |
| Common: Diarrhea, nervousness, drowsiness, headache, increased sweating, insomnia, anxiety. |
Continue taking medication. Call doctor when convenient. |
| Infrequent: Chills, fever, joint or muscle pain, enlarged lymph glands, unusual excitability, blurred vision, chest pain. |
Discontinue medication. Call doctor right away. |
| Nightmares, taste changes, vision changes, decreased sex drive, dry mouth, skin flushing, urinating frequently, painful menstruation, stuffy nose, tremors. | Continue medication. Call doctor when convenient. |
| Rare: Seizures. (convulsions). |
Discontinue medication. Seek emergency treatment. |
| Fast heartbeat; abdominal pain; signs of low blood sugar (anxiety, nervousness, chills, increased sweating, difficulty concentrating). | Discontinue medication. Call doctor right away. |
| Nausea, vomiting, constipation, cough, increased appetite. | Continue medication. Call doctor when convenient. |
Adverse reactions and side effects may be more frequent and severe in those over age 60 than in younger persons. You may need smaller doses for shorter periods of time.
Warnings & Precautions
Don't take if you are allergic to fluoxetine.
Before you start, consult your doctor:
| If you have a history of seizure disorders. |
| If you have severe liver or kidney disease. |
Others
| Advise any doctor or dentist whom you consult about the use of this medicine. |
| For dry mouth, suck on sugarless hard candy or chew sugarless gum. If dry mouth persists, see your dentist. |
| Don't discontinue without consulting doctor. |
Interactions
| Possible Interaction With Other Drugs | |
| Generic Name Or Drug Class | Combined Effect |
| Anticoagulants, oral | Increased risk of bleeding. |
| Anticonvulsants | Increased risk of anticonvulsant toxicity. |
| Antidepressants, tricyclic | Increased levels of tricyclic antidepressant; possible toxicity. |
| Bupropion | Increased risk of seizures. |
| Central nervous system (CNS) depressants | Increased depressant effects of both drugs. |
| Clozapine | Increased risk of adverse clozapine reactions. |
| Doxfonfluramine | May cause serotonin syndrome. Avoid. |
| Lithium | Risk of increased lithium effect. |
| Monoamine oxidase (MAO) inhibitors | May cause confusion, agitation, convulsions, high blood pressure. Possibly life-threatening. Allow 4-5 weeks between use of these drugs. |
| Selegiline | Increased risk of adverse effects. May lead to convulsions and hypertensive crisis. Let 14 days elapse between taking the 2 drugs. |
| Possible Interaction With Other Substances | |
| Interacts With | Combined Effect |
| Alcohol | Possible toxicity of both drugs. Avoid. |
| Beverages with caffeine | Decreases effect of fluoxetine. |
| Cocaine | Decreases effect of fluoxetine. |
| Marijuana | Decreases effect of fluoxetine. |
| Tobacco | Decreases effect of fluoxetine. |
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